| Description |
The topic of the thesis will be the development of new polymeric carriers of anticancer drugs for their local application. In the treatment of solid tumors, the local drug application has a number of advantages compared to systemic application. It allows for a higher drug concentration in the target tumor cells for a longer time, with a lower overall dose administered to the body. Polymeric carriers can be, for example, in the form of hydrogels or nanofibers. The work will focus on the preparation of carriers, characterization of their properties (morphology, physical parameters, the interaction of active substance - polymer), and testing the release kinetics in laboratory conditions. Part of the development of polymeric carriers is also testing their biological activity in vitro on cell lines and in in vivo conditions. The aim of the work is to describe the consequences of the preparation of carriers, their parameters, drug release kinetics, and their behavior in the in vivo environment. The interdisciplinary work at the border of polymeric, organic, and analytical chemistry can be adapted according to the applicant's qualifications. The thesis will be elaborated on in cooperation with Czech and foreign collaborating institutions. |
