| Topic |
Actively Targeted self-organized systems |
| Supervisor |
Miroslav Vetrík, Ph.D. |
| Consultant |
Prof. Mgr. Martin Hrubý, DSc |
| Department |
Supramolecular Polymer Systems
|
| Description |
The present dissertation deals with the synthesis, characterization, and in vitro testing of self-ordered molecules forming nanoparticles (micelles/liposomes) with a hydrophobic core and hydrophilic parts of the molecule. The hydrophilic part of the molecule will be functionalized with functional groups affecting the surface charge of the nanoparticle and functional groups actively targeting e.g., tumors. The core of the nanoparticle will contain therapeutic drugs which will be delivered directly into the intracellular compartments. In this work, the low molecular weight agents prepared in this way with different functionalities on the hydrophilic part of the chains will be combined to achieve the best therapeutic effect. The scope of the thesis will be organic synthesis, and physicochemical characterization. The thesis involves the use of animal/human cell lines in performing basic in vitro techniques with which the student will be familiar. |
| Universities |
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