| Description |
Encapsulation of active pharmaceutical ingredient into drug delivery systems such as self-assembled polymer structures can alter in a desired way biodistribution and pharmacokinetics of such drug and may also prolong its blood circulation time in vivo. However, after administration into organism such supramolecular assemblies get into contact with physiological liquids, containing numerous amphiphilic macromolecules and charged surfaces. As a result, the self-assembled structures may undergo complete structural reorganization, which changes their behavior. The thesis will be devoted to the synthesis of amphiphilic polymeric carriers based on poly (2-oxazolines) or poly(2-oxazoline)-polysaccharide hybrid polymers, their characterization, and extensive physico-chemical study of their self-assembly and disassembly in solutions containing physiological liquids and living cells. The ultimate goal of the project is the elucidation and generalization of structure-property dependences for the reliable prediction of the in vivo biological behavior of supramolecular polymer drug delivery systems, which is of extreme interest for nanomedicine. The optimized delivery systems will be offered for in vitro and in vivo biological testing at collaborating institutions. |
