| Description |
The topic is based on the main concept of tissue engineering – combination of stem cells and supporting polymer scaffold. In specific branches of tissue engineering ultrathin and highly porous membranes are demanded to serve as temporary substitutes of basal membrane either for cell cultivations or for cell transfer into a tissue lesion during transplantations. The aim of the PhD thesis is designing of nanofibrous membranes based on biodegradable polymers such as poly(amino acid)s. Nanofibrous substrates should mimic tissue not only from morphological point of view (e.g. with suitable porosity) and by adequate mechanical properties, but also with relevant cell interactions with polymer scaffold. Based on the knowledge of cell interactions with proteins of extracellular matrix, the novel nanofibrous scaffold will be designed in the way of evoking a physiological response, as e.g. cell growth and differentiation. Applicant should have skills in field of macromolecular chemistry and organic synthesis. Project will be solved in collaboration with Czech and international biological departments. |
