Polymeric systems for the treatment of metastatic tumors
The research topics addressed by scientists from the Department of Biomedical Polymers is also the study of new medical approaches that could effectively prevent the spread of metastases during and after the treatment of primary tumors. A new study by scientists from the IMC appeared as the cover story of the August issue of the journal Nanomedicine: Nanotechnology, Biology, and Medicine.
The researchers described the design, controlled synthesis and detailed physicochemical and biological characterization of a novel panel of defined water-soluble actinonin-bearing polymer conjugates for advanced drug delivery and metastasis inhibition. “Different synthetic approaches were employed for covalent attachment of actinonin to water-soluble copolymers to control the release rate of actinonin into its pharmacologically active form. The developed nanosystems with favorable drug release kinetics inhibited the metastatic spread of cancer cells from primary 4T1 tumors to the lung and the invasion of B16F10 melanoma cells from the circulation to the lung without any sign of toxicity in healthy tissue,” says Dr. Tomáš Etrych, head of the Department of Biomedical Polymers. Researchers from the Institute of Macromolecular Chemistry of the Czech Academy of Sciences collaborated on the research with scientists from the Institute of Microbiology of the Czech Academy of Sciences.