Polymer nanoparticles for the diagnosis of cardiovascular diseases

Researchers from the Institute of Macromolecular Chemistry have achieved success in the field of light-converting nanoparticles for bioanalytical applications. Their study describing the development of polymeric nanoparticles suitable for cardiac troponin detection was published in the prestigious journal Talanta. Researchers from the IMC cooperated with the team of Dr. Zdeněk Farka at the CEITEC Research Center.

Surface engineering of light-converting nanoparticles is essential for bioanalytical applications. Researchers from the Department of Polymer Particles (IMC) covalently bound an antibody specific for cardiac troponin, which is an important biomarker in the diagnosis of acute myocardial infarction. To successfully bind the target biomolecule, anti-troponin, the researchers were able to modify light-converting nanoparticles that emit high-energy visible light when irradiated with low-energy surface infrared radiation. “Due to the knowledge gained in the research of magnetic nanoparticles and thanks to the dexterity of the then PhD students (now postdoctoral students) we finally managed to reproducibly synthesize monodisperse light-converting particles of excellent quality,” describes Dr. Daniel Horák, Head of the Department of Polymer Particles.

The Original Article

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