News archive

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RGD-coated polymeric microbubbles enable drug delivery across the blood-brain barrier
We discovered that sonopermeation with microbubles enhances delivery across the blood-brain barrier of both nanocarriers and free drugs.
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Advanced polymeric vectors for the treatment of site-specific rheumatic musculoskeletal diseases
Researchers from ÚMCH, together with colleagues from BFU and the Institute of Rheumatology, developed polymer vectors with optimized drug activation for the treatment of rheumatic diseases.
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Effect of Polymer Concentration on the Morphology of the PHPMAA-g-PLA Graft Copolymer Nanoparticles Produced by Microfluidics Nanoprecipitation
Researchers from IMC have demonstrated the feasibility of preparing PHPMAA-g-PLA polymer nanoparticles with various morphologies using microfluidic channels.
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Polymeric adjuvants designed to increase the efficiency of polymer nanosystems in tumor therapy
We have developed a polymer nanosystem that can increase the uptake of other therapeutic nanosystems in tumor tissue, thereby significantly increasing their therapeutic efficacy.
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Nano-FTIR spectroscopy of surface confluent polydopamine films
Nanoscale infrared characterization of polydopamine layers was published in Colloids and Surfaces B: Biointerfaces.
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Electrodestruction of bacterial biofilm on polymer layers
Scientists from the IMC have developed polymer layers capable of significantly increasing the efficiency of electrosterilization of surfaces with bacterial biofilm.
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Highly effective synthetic polymer-based blockers of non-specific interactions
Researchers from IMC have developed highly effective synthetic polymer blockers of non-specific interactions, which make it possible to replace currently used proteins of animal origin.
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Polymersome nanovaccines enhance antitumor immunity with co‑delivered antigens and adjuvants
IMC and Radboud University Medical Center developed polymersome nanovaccines boosting antitumor immunity by co-delivering antigens and adjuvants to dendritic cells.
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Aluminosilicate networks as Lewis acid catalysts: Synthesis and characterization
The journal Inorganic Chemistry has published a comprehensive study that reveals the mechanism of formation of catalytically active aluminosilicate networks and provides a detailed insight into the structure of the resulting Lewis acid centers.
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Cancer cell membrane targeting with tailored highly defined polymers
Scientists from the IMC CAS developed in collaboration with the IOCB CAS highly defined "octopus" peptoid polymers targeting cancer cell membranes.
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Degradation of polyolefins with phenolic stabilizers subjected to ionizing or non-ionizing radiation
IMC researchers showed that phenolic stabilizes (such as vitamin E) exhibit both antioxidant and prooxidant properties, depending on the irradiation type.
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Sustainable aerogels made of poly (itaconic acid) for wastewater remediation
International Journal of Biological Macromolecules recently published the use of aerogels for dyes adsorption. These aerogels are considered a promising adsorbent material for wastewater remediation.
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Non-conventional light-mediated therapy with ferrocene-based polymer micelles
Scientists from the IMC developed non-conventional light-triggered approach to killing cancer cells using ferrocene-containing polymer micelles.
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Tannic acid-modified magnetic nanoparticles reduce oxidative stress in liver
Magnetic iron oxide nanoparticles modified with tannic acid and N-acetylcysteine-chitosan conjugate reduce oxidative stress in liver of prediabetic rats.
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38 nm biodegradable poly[N-(2-hydroxypropyl) methacrylamide] nanogels by dispersion polymerization
The scientists from the IMC developed the conditions of dispersion polymerization for the preparation of 38 nm core shell biodegradable, hydrophilic and reactive nanogels.
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Biobased ultralow-density polyurethane foams with enhanced recyclability
We have prepared ultra-light polyurethane foams from renewable feedstock showing increased recyclability, which contribute to circular economy and solving plastic waste concerns.
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Novel natural-based alginate-pectin networks dually crosslinked with Ca2+/Zn2+ ions for the delivery of lipophilic phytotherapeutics
The close collaboration of the IMC CAS, MUNI Pharm and VRI resulted in the design of advanced hybrid alginate-pectin networks, proposed as the long-term site-specific treatment of intestinal inflammation.
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Mechanically strong and extensible monolithic hydrogels with rapid response to temperature change
Strong and tough monolithic non-porous hydrogels have been developed: poly(N-isopropylacrylamide) interlaced with hydroxypropylmethylcellulose. Some exhibited an exceptionally rapid response to temperature changes.
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New highly hydrophilic methacrylamide-based drug carriers for cancer treatment
We have designed, synthesized and tested in vivo efficient water-soluble polymer chemotherapeutics that are able to be accumulated in tumor tissue.
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Polymerization of renewable itaconic acid in deep eutectic monomers
Scientists from IMC in cooperation with Polish colleagues, synthesized polyitaconates from renewable resources as more environmental-friendly alternatives to conventional petrochemical polyacrylates.
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