Surface-engineered lanthanide nanoparticles for biomedicine

Mykhailo Nahorniak
Přednáška cyklu VIS
19.2.2026 10:00, Přednáškový sál A

This work aimed to develop novel upconversion nanoparticles (UCNPs) with controlled size and enhanced luminescence for photodynamic therapy. Control over particle size was achieved through a hybrid high-temperature coprecipitation–hydrothermal synthesis that enabled the precise tuning of particle size from ultrasmall (<10 nm) to large (>200 nm) by adjusting the water content. A core–shell architecture significantly enhanced upconversion luminescence by suppressing surface quenching. Further surface-engineering of UCNPs with silica increased their colloidal stability and cellular uptake, while their modification with bisphosphonate-terminated polyethylene glycol (PEG) improved aqueous stability and limited ion release. To create near-infrared-activated photodynamic theranostic agents capable of inducing phototoxic effects in tumour cells by generating singlet oxygen, but also characterized by low dark toxicity, a phosphonate-modified Rose Bengal photosensitiser was conjugated to PEGylated UCNPs nanoparticles.

Přednáška je vedena v anglickém jazyce