Ústav makromolekulární chemie AV ČR

Magnetic nanoparticles with antibacterial properties: Synthesis, characterization and biological applications

Mgr. Anastasiia-Bohdana Shatan
Přednáška cyklu VIS
25.4.2024 11:00, Přednáškový sál A

In response to the escalating global threat of antibiotic resistance, innovative strategies for treatment of bacterial infections are imperative. The presented work is focused on surface-engineered magnetic nanoparticles with potent antibacterial properties, aiming to combat antibiotic resistance effectively. Specifically, Fe3O4 nanoparticles were synthesized and modified with silica using a water-in-oil reverse microemulsion followed by subsequent decoration with silver nanoclusters. Optionally, Fe3O4 particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups facilitating attachment to the iron oxide and enabling (co)polymerization with 2-(dimethylamino)ethyl methacrylate and/or 2-tert-butylaminoethyl methacrylate. Furthermore, antimicrobial γ-Fe2O3 nanoparticles were synthesized and modified with biocompatible dextran, to which β-cyclodextrin was covalently linked forming a non-covalent complex with silver-sulfameth strong azine. The resulting surface-modified iron oxide nanoparticles demonstrated strong in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and fungi (Candida albicans and Aspergillus niger). The synergistic combination of magnetic properties and bactericidal effects holds promise for application of newly developed particles in medical instrument disinfection, water purification, food packaging, etc.

Přednáška je vedena v anglickém jazyce