| Description |
The self-assembly of macromolecules represents a fundamental organizational principle of living matter. Supramolecular assemblies intended for drug delivery must exhibit sufficient stability in the biological systems. This project will investigate a family of medically relevant poly(2-oxazolines) with tunable molecular architectures, including adjustable hydrophobicity, chain morphology, and charge density, to develop stimuli-responsive theranostic systems. The systems will be designed to respond to changes of especially pH, temperature and to the presence of reactive oxygen species allowing precise control over bioactive cargo delivery and release. Comprehensive physicochemical characterization of their self-assembly behavior and stability will be performed in solutions containing physiological fluids and living cells using spectroscopic, calorimetric, and scattering techniques. The research will be conducted on both model and real drug-delivery platforms, with flexibility to accommodate the student’s research interests. The optimized delivery systems will be submitted for in vitro and in vivo evaluation at collaborating institutions. |
