| Description |
Accurate tumor resection without unnecessary removal of healthy tissue is crucial for successful oncological surgery. In oncological endoscopic surgery, defining tumor borders remains a challenge. Visual distinction between malignant and healthy tissue is often difficult, making adequate tumor margins essential for a good prognosis in head and neck squamous cell carcinoma. The aim of the theses will be to design and synthesize biodegradable, activatable and biocompatible polymer-based theranostic nanoprobes suitable for targeting the system to the tumorous tissue first to visualize the tumor tissue for surgeon by control activation of the cargo fluorescence emission and second enable the postsurgical PDT of the tumor bed to eradicate the rest of the tumor cells left behind the surgery. As part of the work, close cooperation with the Universital hospital Motol and University of Grenoble is expected. |
