Institute of Macromolecular Chemistry
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Topic Self-assembled multiresponsive polymer systems for biomedical use
Supervisor Petr Štěpánek, DSc
Consultant Martin Hrubý, DSc
Department Supramolecular Polymer Systems
Description Self-assembly of (macro)molecules is of crucial importance in the architecture of living organisms. Examples of such natural supramolecular nanostructures are multienzyme complexes, ribosomes or cytoplasmic membranes. Such supramolecular systems have their key properties critically dependent on self-assembly. Nanoparticles are the most important type of such synthetically prepared systems. They find use in the area of biomedical applications especially if they are able to reversibly react to external stimuli (changes in pH, light, redox potential, ultrasound, temperature, concentration of certain substances). The doctoral thesis will be based on chemical and/or physicochemical preparation, study of self-assembly and interactions of such multi-stimuli-responsive nanoparticles with external environment (with emphasis on pH, redox potential, calcium concentration and temperature responsiveness); the exact topic will take into account the student´s interests. The studied nanoparticles will be designed for diagnostics and personalized therapy of cancer and infectious diseases. The key part of the thesis will be the use of advanced characterization methods, for example static, dynamic and electrophoretic light scattering, small angle X-ray and neutron scattering, isothermal titration calorimetry and fluorescence correlation spectroscopy. Optimized nanoparticles will be then provided to collaborating biological workplaces for testing in real applications.
It is possible to make a part of the study at collaborating workplace in France within the Barrande program “double degree PhD”, the deadline for applications February 14, 2020 (see https://studium.ifp.cz/cz/doktorandi/barrande-fellowship-program/ ). If you are interested in this option, please contact the supervisor as soon as possible.
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