Institute of Macromolecular Chemistry
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Topic Physicochemical and biological properties of nanoparticles made of amphiphilic copolymers with different architectures
Supervisor Jiří Pánek, PhD
Consultant Lenka Loukotová, PhD
Department Supramolecular Polymer Systems
Description The curiosity-driven aim of the project is to compare physico-chemical and biological properties of nanoparticles prepared by self-organization of various amphiphilic copolymers in aqueous milieu; the thesis is expected to answer the question if we should prefer block or gradient copolymer for purposes of biomedical applications. The ability of the nanostructures to encapsulate active molecules will be assessed - for instance therapeutic compounds (anti-inflammatory, anticancer), imaging agents (fluorescent dyes for IR region), or inorganic probes (iron oxides for MRI) might be tested. The encapsulation of active molecules during formation of nanoparticles strongly depends on the experimental setup therefore microfluidics devices providing reproducible and stable preparation conditions will be used. Exploited characterization techniques include UV/VIS spectrometry, scattering techniques or fluorescence correlation spectroscopy; finally, the biological properties of the prepared systems will be tested in vitro and in vivo at collaborating biological laboratories. On the basis of our preliminary results, the gradient polymers are highly prospective for intended applications. The topic is multidisciplinary and might be further adjusted according to the individual interests of a student.
It is possible to make a part of the study at collaborating workplace in France within the Barrande program “double degree PhD”, the deadline for applications February 14, 2020 (see https://studium.ifp.cz/cz/doktorandi/barrande-fellowship-program/ ). If you are interested in this option, please contact the supervisor as soon as possible.
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