Publications & Patents - Polymer and Colloid Immunotherapeutics

Publications

We regularly publish the results of our research in prestigious peer-reviewed journals. We prefer journals thematically focused on polymer and colloid chemistry, drug delivery and imaging technology, or a combination of the above topics.

Selected recently published articles:

Lynn, R. Laga, P. Darrah, A. Ishizuka, A. Balaci, A. Dulcey, M. Pechar, R. Pola, M. Gerner, A. Yamamoto, J. Meyerson, K. Quin, M. Smelkinson, O. Vanek, R. Cawood, T. Hills, O. Vasalatiy, K. Kastenmuller, J. Francica, T. Etrych, K. Fisher, L. Seymour, R. Seder

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

Nature Biotechnology 33 (2015), 1201-1210.

R. Francica, R. Laga, G. M. Lynn, G. Mužíková, L. Androvič, B. Aussedat, W. E. Walkowicz, K. Padhan, A. Ramirez-Valdez, R. Parks, S. D. Schmidt, B. J. Flynn, Y. Tsybovsky, G. B. E. Stewart-Jones, J. M. Steichen, K. O. Saunders, F. Baharom, W. R. Schief, C. Petrovas, B. F. Haynes and R. A. Seder

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native Envelope antibody responses in nonhuman primates

PLOS Biology, 17/6 (2019), e3000328 .

M. Lynn, P. Chytil, J. R. Francica, A. Lagova, G. Kueberuwa, A. S. Ishizuka, N. Zaidi, R. A. Ramirez-Valdez, N. J. Blobel, F. Baharom, J. Leal, A. Q. Wang, M. Y. Gerner, T. Etrych, K. Ulbrich, L. W. Seymour, R. A. Seder, and R. Laga

Impact of polymer-TLR-7/8 agonist (adjuvant) morphology on the potency and mechanism of CD8 T cell induction

Biomacromolecules, 20/2 (2019), 854-870.

Paúrová, I. Šeděnková, J. Hromádková, M. Babič

Polypyrrole nanoparticles: control of the size and morphology

Journal of Polymer Research. 27/12 (2020), 366.

L. Androvič, L. Woldřichová, K. Jozefjaková, M. Pechar, G. Lynn, D. Kaňková, L. Malinová, R. Laga

Cyclotriphosphazene-based star copolymers as structurally tunable nanocarriers with programmable biodegradability

Macromolecules. 54/7 (2021), 3139-3157

M. Paúrová, O. Taboubi, I. Šeděnková, J. Hromádková, P. Matouš, V. Herynek, L. Šefc, M. Babič

Role of dextran in stabilization of polypyrrole nanoparticles for photoacoustic imaging

European Polymer Journal, 157 (2021), 110634

P. Keša, M. Paúrová, M. Babič, T. Heizer, P. Matouš, K. Turnovcová, D. Mareková, L. Šefc, V. Herynek

Photoacoustic Properties of Polypyrrole Nanoparticles

Nanomaterials, 11/9 (2021), 2457

L. Kracíková, N. Ziółkowska, L. Androvič, I. Klimánková, D. Červený, M. Vít, P. Pompach, R. Konefał, O. Janoušková, M. Hrubý, D. Jirák, R. Laga

Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for 31P-Magnetic Resonance Imaging

Macromolecular Bioscience, 22/5 (2022), 2100523

L. Kracíková, L. Androvič, L. Schindler, G. Mixová, M. Babič, M. Paúrová, M. Filipová, J. Hromádková, D. Kaňková, M. Pechar, G. Lynn, D. Červený, D. Jirák, R. Laga

Polymer-colloidal systems as MRI-detectable nanocarriers for peptide vaccine delivery

European Polymer Journal, 181 (2022), 111704I.

Šeděnková, O. Taboubi, M. Paúrová, J. Hromádková, M. Babič

Influence of the type and concentration of oxidant on the photoacoustic response of polypyrrole nanoparticles for potential bioimaging applications

Synthetic Metals, 292 (2023), 117218

Patents

Lynn, R. Laga, K. Fisher, R. Seder, L. Seymour; Temp-Sensitive Polymer Adjuvant, UK Patent Application No. 1418004.6 (2014).

Lynn, Y. Zhu, J. Holechek, D. Wilson, J. Francica, R. Laga, G. Mužíková; Compositions and methods of manufacturing star polymers for ligand display and/or drug delivery, PCT/US20/28586 (2020).

G. Lynn, D. Wilson, E. Wang, L. Woldřichová, L. Androvič, R. Laga; Compositions and methods of manufacturing amphiphilic block copolymers that form nanoparticles in situ, provisional patent application US 63/081,729 (2020).