PIPOx Modification: Your Shortcut to Functional Polymers for Diverse Applications

Vladimír Raus
Lecture of the lecture cycle
25.9.2025 10:00, Lecture room A

Poly(2-isopropenyl-2-oxazoline) (PIPOx) has recently emerged as a versatile platform for post-polymerization modification, enabling access to functional polymethacrylamides with broad applicability. Until recently, progress in this area was hindered by the limited efficiency of the commonly employed reactions with carboxylic acids. We have now overcome this bottleneck by introducing more effective modifications with thiols. Through both direct thiol additions and indirect para-fluoro–thiol click reactions, we obtained polymers with different side-chain functionalities, including ionizable groups, non-polar moieties of various sizes and structures, supramolecular motifs, glycosides, amino acids, peptides, nucleobases, fluorescent tags, drugs, crosslinkers, and polymeric chains. Furthermore, combinations of thiols allowed us to prepare multifunctional copolymers with precise, stoichiometric control over composition. The lecture will present both published and unpublished results, aiming to highlight the advantages of the PIPOx platform and encourage its adoption in polymer research at IMC.

The lecture is presented in English