Dr. Richard Laga
TopicAdvanced macromolecular vaccines against cancer diseases
AnnotationIn the last few years, there have been prevailing efforts of scientists to use a cooperation of chemical and immunological methods in the treatment of malignant tumors. The major goal of this combined chemico-immunological approach consist in recognition and disruption of tumor cells by own immune system of a patient, activated by a suitable immunotherapeutics (so called tumor specific antigen), followed by stopping growth or killing of tumor cells by a cytostatic agent. However, despite of reached successes, the treatment of malignant diseases by both chemical and immunological method yields some restrictions. There are namely lower efficiency in the treatment of tumors composed of heterogeneous cell populations in the case of immunological approach and cytotoxicity of a cancerostatic agent on healthy tissues and short-term effect in the case of chemical approach. Biocompatible multivalent polymers offer an elegant solution of these problems as they can serve as high-molecular-weight transport systems for both tumor specific antigens and cancerostatics. The aim of this study will be the development of polymer-immunothrapeutics/cancerostatics conjugates, which elicit potent and durable immune response against the tumor cells as well as reduce side effects of the cancerostatics and ensure its enhanced accumulation inside the tumor tissues. Specifically, the project will deal with the preparation and physicochemical characterization of the synthetic polymer-antigen/adjuvant/cancerostatics conjugates. The accent will be put on the study of polymer chain composition, architecture and hydrodynamic behavior or way of the therapeutics attachment to the polymer carrier with respect to the biological behavior of the conjugates in vivo. Biological testing will be provided at both domestic and foreign partner sites.
UniversitiesVysoká škola chemicko technologická v Praze, Přírodovědecká fakulta UK, Přírodovědecká fakulta Univerzity Palackého Olomouc, Universita Tomáše Bati Zlín

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
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162 06 Prague 6
Czech Republic
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