Supervisor
(Consultant)		Jindřich Hašek
TopicFunction principles of organized macromolecular systems
AnnotationAll live organisms depend on self-organization and destruction of very well spatially organized supra-molecular systems working as perfect machines of nanometer dimensions. Current experimental and theoretical methods for structure analysis allow detailed understanding of these bio-molecular systems - signaling, catalysis of chemically impossible syntheses, controlled adhesion, etc. Control of these molecular machines offers an infinite number of attractive applications in medicine, agriculture, industry, ecology, etc. Our laboratory specializes to: (1) development of safer and more efficient drugs with known paths of action in the body, (2) development of materials with minimum antigen response (implants, diagnostics) (3) function analysis of receptors of the immune system cells, (4) detailed analysis of enzymatic function and optimization of properties for use in many areas of industry and public life. The PhD thesis is oriented preferentially to (2) and (3). Student should work with structure databases, model intermolecular interactions, classify interactions between synthetic polymers and bio-macromolecules, and determine protein structures using diffraction methods. The final aim of the work is practical application in more safe methods used in medicine and improvement of environmental care. Student will be responsible for maintenance of databases describing behavior of synthetic polymers in biological environment.

Center BIOPOL

Center BIOpolymer POstdoctoral Laboratory and educational center arises with finantial support from EU funds, operational programme Education for Competitiveness

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410