Jiří Brus, PhD
Consultant Larysa Starovoytová, PhD
TopicStructure and conformational dynamics of thermoresponsive polypetides and oligopeptides.
AnnotationThe proposed project is based on the study of structure and of conformational dynamics of peptides and polypeptides that form specific blocks of synthetically modified copolymers intended for biomedical applications. Particular attentions will be aimed to the location and characterization of water molecules in spatial proximity of polymer chains. Furthermore, the overall changes of the domain size of both polymer components and morphology of these copolymer systems will be evaluated. To investigate the interaction of hydrophobic and hydrophilic polypeptides with water systematically a series of short model sequences will be used. The oligopeptides will be uniformly labelled by 13C and 15N. The main technique used for the conformational study is high-resolution NMR spectroscopy (1H operation frequency is 600 MHz).

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21