MS. Daniel Horák, PhD.
TopicMagnetic nanoparticles with antibacterial properties: Synthesis, characterization and biological applications
AnnotationBiofilm formation and dissemination of antibiotic-resistant pathogenic bacteria by indirect transmission through contaminated surfaces and medical devices is becoming a major global public health threat. The problem can be solved by designing new nanocomposite particles engineered with antibacterial properties to target bacteria. The aim is to anchor or encapsulate antibacterial agents, e.g., metallic (Ag) nanoparticles prepared by reductive methods, in a carrier to make them insoluble and colloidally stable, retain their properties, and offer high surface area available for interactions with bacteria. To obtain easily manipulatable, targetable, and separable particles from liquid media, magnetic carriers will be preferred. Superparamagnetic iron oxide nanoparticles will be therefore prepared with synthetic conditions controlled by selection of the reaction parameters, which will be correlated with properties of the particles. Subsequently, their surface will be modified with antibacterial agents, such as silver. Physicochemical and antibacterial properties of the nanoparticles will be evaluated. The nanoparticles with the surface shell exhibiting a maximal antibacterial activity will be offered for commercialization.
UniversitiesVysoká škola chemicko technologická v Praze, Přírodovědecká fakulta UK

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
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