Supervisor
(Consultant)
MSc.Vladimír Proks, Ph.D.
TopicInjectable biomimetic hydrogels for regenerative medicine
AnnotationThe in situ formed biomimetic hydrogels represent very attractive class of biomaterial scaffolds for regenerative medicine. Up to date, no injectable biomaterials that would allow full tissue regeneration are available. Development of biomaterials imitating ECM regeneration in the body would be useful for various types of surgical and orthopaedic procedures. The aim of the project is to design injectable, in situ formed hydrogels that could be used as an artificial ECM environment for matrix-assisted cell therapy and tissue regeneration. The dissertation will focus on design, synthesis and study of physicochemical properties of polymeric precursors based on synthetic polypeptides and natural polysaccharides. Furthermore, a gelation protocol will be developed to establish a hydrogel network, which could ensure mechanical protection of cells from shear forces and promote cell retention and engraftment. Hydrogels will be modified with biomimetic structures, e.g., cell-adhesion peptides that would promote specific interactions with cells and growth factors. Knowledge and skills in macromolecular and organic chemistry is expected as well as willingness to improve knowledge in biochemistry and biology. Student will learn various techniques and methods using modern measuring instruments.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21