Supervisor
(Consultant)
Dana Kubies, PhD
TopicSelf-assembled multilayer film coatings of biomaterials for protein release.
AnnotationThe important factor supporting integration of biomaterials with the tissue of recipient in biomedical applications is immobilization of biologically active substances on the biomaterial surface. The layer-by-layer (LbL) method is a powerful technique for the fabrication of multilayer films by complementary interactions between components, such as positively and negatively charged polymers. The technique has been also used to produce biocompatible self-assembled coatings as a reservoir of biomacromolecules. The project aims to obtain a hydrolytically degradable multilayer coating via LbL method for sequential release of growth factors and to study the assembly/disassembly dynamics, the physicochemical and morphological properties of the coatings. The effect of the immobilized growth factors on proliferation and differentiation of cells in vitro will be evaluated in cooperation with a biological laboratory. The topic is appropriate for graduate students in Chemistry, particularly macromolecular chemistry, physical chemistry or eventually biochemistry.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21