Supervisor
(Consultant)
Michal Pechar, PhD
TopicNew Generation of Targeted Polymer Therapeutics
AnnotationCombination of synthetic and natural macromolecules may provide new sophisticated materials. Some of the polymer systems can be used for controlled drug release and targeted drug delivery. Hydrophilic synthetic polymers containing various biologically active peptides and proteins will be designed and synthesized in this project. The peptides or proteins (e.g. antibodies and antibody fragments) will be used as targeting ligands enabling enhanced accumulation of the polymer drug conjugate in the site of desired therapeutic effect. We will optimize the methods of attachment of the targeting ligands to the polymer carrier with the aim to preserve the biological activity. One possibility is to take advantage of non-covalent interaction between peptides (e.g. a coiled coil interaction). The polymer carriers will be based mostly on copolymers of N-(2-hydroxypropyl)methacrylamide or poly(ethylene glycol). The properties of the polymer systems will be thoroughly studied using various physico-chemical methods, e.g. liquid chromatography, mass spectroscopy, light scattering, circular dichroism and NMR. Biological properties will be studied in collaboration with another institutions.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21