|Martin Hrubý, PhD|
Consultant Martin Kuchař, M.Sc., Ph.
|Topic||Polymer nanoreactors for biomedical applications|
|Annotation||Damage of neural tissue due to mechanical trauma or hindered oxygen supply (e.g., brain stroke) belongs to major causes of permanent handicaps. Significant part of the neural tissue damage is caused by secondary damage due to defensive reaction of the organism. The aim of the dissertation thesis is to synthesize and study properties of biocompatibilized biodegradable implantable polymer nanoreactors that catalytically degrade mediators of secondary damage of neural tissue (glutamate - causing excitoxicity, reactive oxygen species - causing oxidative stress) and release in a controlled manner biologically potent neurotransmitter analogs stimulating proliferation of neural progenitor cells. The latter are of key importance for neural tissue repair. The work will consist in synthesis and characterization of polymers, in nanoreactors and neuroactive neurotransmitter analogs and in characterization of properties and catalytic efficiency of nanoreactors and of their ability to release bioactive substances. Samples will then be submitted to collaborating biological institutes for biological evaluation, evaluation of results will be carried on in correlation with the chemical part of the project.|
BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL
Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW
Centre of Biomedicinal Polymers - CBMP
Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
phone:+420 296 809 111
fax:+420 296 809 410