Supervisor
(Consultant)
Martin Hrubý, PhD
TopicDevelopment, analysis and characterization of structure of self-assembled nanoparticulate delivery systems for biologically active compounds by advanced instrumental methods
AnnotationThe aim of the thesis is development, detailed analysis and characterization of structure of self-assembled nanoparticle delivery systems for biologically active compounds by advanced instrumental methods. Sterically and electrostatically stabilized nanoparticle formulations containing therapeutically active components (e.g., natural immunomodulators, metal ion chelators or antibiotics) noncovalently entrapped inside the particle core will be prepared by nanoprecipitation. The nanoparticles will be studied in detail by static, dynamic and electrophoretic ligh scattering, X-ray and neutron scattering and fluorescence techniques. Characterization of these systems will be amended by separation techniques - field flow fractionation, gel permeation chromatography to study the starting polymers for the preparation of nanoparticles and also by conventional chromatographic techniques for the determination of active components.. The analytical methods will be optimized for analysis of complex systems. The systems will be subsequently tested at collaborating institutions both in vitro and in vivo.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21