Jan Dohnálek, PhD.
Consultant Dr.Tereza Skalova, PhD
TopicStructure and function of biological macromolecules with applications in biotechnologies.
AnnotationProcesses of life are on molecular level carried out by proteins, DNA, RNA or their complexes. The specific functions of these biological molecules are closely related to their structural characteristics. Many enzymes and other proteins are also exploited in food processing, medicine, materials processing or military applications especially for their very specific properties. With use of x-ray diffracion methods it is possible to determine accurately the three-dimensional structure of biological molecules and in this way explain their function from the point of view of their three-dimensional arrangement. These approaches will be applied in studies of new enzymes for biotechnological applications (laccases, oxidases, proteases and other). One specific class of enzymes studied intensively in our laboratory are enzymes dependent on transition metals such as Cu, Zn or Mn. The project includes collaboration with an industrial partner, protein characterisation, crystallization and modification, x-ray diffraction experiments, utilization of the European synchrotron radiation sources, structure determination and interpretation.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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