Jan Dohnálek, PhD
TopicStructural analysis of bio-macromolecules applicable in fight against cancer.
AnnotationNucleases are small enzymes degrading nucleic acids critical for cell life. Currently novel plant nucleases are studied with weaker side effects when applied to living organisms. These molecules have significantly different architecture and properties in comparison with standard nucleases and ribonucleases commonly applied in this field and therefore a thorough study of their structure and function is required. The project involves protein characterisation, modification and crystallisation, X-ray diffraction experiments, data collection and synchrotron radiation sources, structure solution and refinement, structure interpretation, mutation design, computational analysis.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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