Petr Štěpánek, DSc
Consultant Martin Hrubý, M.Sc., Ph.
TopicThermoresponsive polymers for local therapies
AnnotationTermoresponsive (sometimes also so-called thermosensitive) polymers with a lower critical solution temperature are soluble at low temperature and precipitate at cloud point temperature. Particularly important are the polymers which can achieve this phase transition in an aqueous environment at physiological temperatures near 37 ° C. These polymers can therefore be injected into a tissue forming nanostructured depot, useable, for instance for brachytherapy of solid tumors (treatment with localized radioactivity carrier) or as scaffolds for regeneration of damaged tissues. The aim of the dissertation thesis is the synthesis and characterization of biocompatible thermoresponsive polymers including hybrid systems and detailed characterization of their phase behavior with physico-chemical methods, namely with scattering of light, X-rays and neutrons. Biological testing of selected samples will be carried on in cooperation with external partners.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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