Petr Štěpánek, DSc
TopicSelf-assembled polymer systems responsive to outer stimuli for biomedicine
AnnotationSelf assembly of (macro)molecules is of crucial importance in the architecture of living organisms. Examples of such natural supramolecular nanostructures are multienzyme complexes, ribosomes or cytoplasmic membrane. Such supramolecular systems have their key properties critically dependent on self assembly and are in fact natural nanomachines. From artifical synthetically prepared systems of this type are most important nanoparticles. Nanoparticles find use in the area of biomedicinal applications especially if they are able to reversibly react to external stimuli (changes in pH, light, redox potential, ultrasound, concentration of certain substances). The doctoral thesis will be based on preparation and study of self assembly and interactions of such stimuli-responsive nanoparticles with external environment (with emphasis on pH, redox potential and ultrasound responsivity). The studied nanoparticles will be designed for diagnostics and personalized therapy of cancer and infectious diseases. The key part of the dissertation thesis will be the use of advanced characterization methods, namely static, dynamic and electrophoretic light scattering, small angle X-ray and neutron scattering, isothermal titration calorimetry and fluorescence correlation spectroscopy. The nanoparticles will be then sent to collaborating biological workplaces for testing and the student will actively participate on evaluation of biological data.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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