Supervisor
(Consultant)
Jiří Pánek, PhD
Consultant Dr Petr Štěpánek, DSc
TopicPolymeric vesicles and their interactions in various environments
AnnotationPreparation of vesicular systems ranks with the most dynamic branches of polymer science. Vesicles represent self-assembled particles consisting of the core - formed by a solvent -surrounded by a bilayer. Among modern methods of preparation those particles belongs nanoprecipitation; it allows reaching significant differences in structure and size of resulting objects, but it is often limited by poor reproducibility. Nevertheless, this disadvantage can be overcome by use, e.g. microfluidic devices. The objective of the study is development and comparison of methods of non-equilibrium self-assembly of block copolymers. The work is further focused on labeling of polymeric vesicles enabling their tracing or imaging, with the use of fluorescent or radioisotope probes or with inorganic nanoparticles. The main focus of the thesis lies in characterization of the prepared systems by microscopy and scattering techniques, fluorescence lifetime imaging microscopy (FLIM), fluorescence correlation spectroscopy and radioisotope imaging. The selected samples will be sent to collaborating biological workplaces for testing their interactions with use of cutting-edge devices; prospective applications of the prepared systems will be considered.
UniversitiesPřírodovědecká fakulta UK, Matematicko-fyzikální fakulta UK, Přírodovědecká fakulta Univerzity Palackého Olomouc, České vysoké učení technické, Universita Tomáše Bati Zlín

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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