Supervisor
(Consultant)
František Rypáček, PhD
Consultant Msc.Vladimír Proks, PhD
TopicBiomaterials with Nanostructured Surfaces for Directed Cell Cultivation
AnnotationIn cell cultures or in tissue engineering, the cultivation substrate/biomaterial scaffold mimics the function of extracellular matrix (ECM). Similarly to ECM, the biomaterial must provide ligands for cell receptors - integrines, analogous to those of ECM by their molecular structure and spatial distribution on the surface. The work objective is to develop selective chemical procedures that would allow us to bind specific focal-adhesion ligands, typically peptide fragments, which would promote formation focal adhesions of cells. For surface modification, the organized molecular layers, e.g. poly(ethylene oxide) brushes, will be prepared taking advantage of a suitable reactive interface, and alkyne-azide cycloaddition (CuAAC "click chemistry") or thiol-olefine (thiol-ene) reactions will be used for selective binding of ligands. New variations of modification reactions will be developed, affording binding of peptide ligands in a specific surface pattern to promote integrin clustering.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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