Supervisor
(Consultant)
Dana Kubies, PhD
TopicSystems for delivery of pro-angiogenic growth factors to support vascularization of polymer scaffolds.
AnnotationIn tissue engineering applications, angiogenesis is considered as a crucial step of the tissue-engineered graft or scaffold integration with the host body. Approaches based on freely administrated growth factors (GF) supporting vascularization (such as VEGF or FGF-2), however, have not led to positive results until now. Therefore methods for introduction of pro-angiogenic factors in a control manner using scaffold-based delivery are intensively investigated. One of the strategies consists in incorporation of GFs into microparticles. The project aims to prepare polyelectrolyte microparticles loaded with GFs, to study their physico-chemical properties, loading efficiency and GF release. Further, the topic is also focused on development of the method for introduction of GF-loaded microparticles into 3D macroporous polymer scaffolds. The effect of the selected approach on vascularization of 3D scaffolds will be evaluated in in vivo experiments in co-operation with biologists and surgeons. The topic is appropriate for graduate students in Chemistry, particularly macromolecular chemistry, physical chemistry or eventually biochemistry.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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