MS Michal Pechar, PhD
TopicNew Generation of Targeted Polymer Cancerostatics
AnnotationCombination of synthetic and natural macromolecules may provide new sophisticated materials. Some of the polymer systems can be used for controlled drug release and targeted drug delivery. Hydrophilic synthetic polymers containing various biologically active peptides or proteins together with cancerostatics will be designed and synthesized in this project. The peptides or proteins (e.g. antibodies and antibody fragments) will be used as targeting ligands enabling enhanced accumulation of the polymer drug conjugate in the site of desired therapeutic effect. We will optimize the methods of attachment of the targeting ligands to the polymer carrier with the aim to preserve the biological activity. One possibility is to take advantage of non-covalent interaction between peptides (e.g. a coiled coil interaction). The polymer carriers will be based mostly on copolymers of N-(2-hydroxypropyl)methacrylamide or poly(ethylene oxide). The properties of the polymer systems will be thoroughly studied using various physico-chemical methods. Biological properties will be studied in biological labs of the institute and also in collaboration with other institutions.
UniversitiesVysoká škola chemicko technologická v Praze, Přírodovědecká fakulta UK, Přírodovědecká fakulta Univerzity Palackého Olomouc

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

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