MSTomáš Etrych, PhD.
TopicBiodegradable polymeric prodrugs for targeted inhibition of the metastatic process
AnnotationMetastatic process is usually a live-limitting factor during the treatmnent of various neoplastic deseases. The major aim of this project is to design, synthesize and study the physico-chemical and biological properties of the biodegradable polymer prodrugs of anticancer drugs and inhibitors of matrix metaloproteasis. Specificity of action will be obtained by their targeting with molecules significantly binding to VEGF or AT1R receptors on the neovasculature of metastases. We suppose that treatment with proposed polymer conjugates will enable simultaneously target several steps involved in the tumor progression and metastatic spread.Polymer drug carriers will be characterized by various physico-chemical methods. Their biological activity will be evaluated in vitro on cell cultures by the student themselves. Further biological evaluation of prepared samples will be solved in cooperation with our local and foreign partner biologicists. The student will broaden their knowledge in the field of novel drug delivery and they will learn new skills of modern polymerization techniques and synthetic and instumental methods.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR
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