INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY
CZECH CHEMICAL SOCIETY
Prague Meetings on
Macromolecules
59th meeting - 40th microsymposium
POLYMERS IN MEDICINE
in honour of 60th birthday of Professor Jindřich Kopeček
PRAGUE, 17 - 20 JULY 2000
PROGRAMME BOOKLET
INSTITUTE OF MACROMOLECULAR CHEMISTRY
ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
PRAGUE, CZECH REPUBLIC
EDITORIAL
40th Microsymposium Programme Booklet published as
Volume K73
ISBN 80-85009-38-2
by the Institute of Macromolecular Chemistry
of the Academy of Sciences of the Czech Republic
Summaries, except for their headings, will be printed without editing.
under the auspices of the
OF PURE AND APPLIED CHEMISTRY
Macromolecular Division
R.G. Gilbert
President of the Macromolecular Division
Organized by the
J. Lukáš
P.M.M. Head
J. Kahovec
P.M.M. Editor
J. Jůza
P.M.M. Assistant Editor
M. Srpová
P.M.M. Secretary
E. Grisová
M. Rodová
P.M.M. Assistant Secretaries
J. Hradil
P.M.M. Technical Manager
D. Kotíková
P.M.M. Social Programme Manager
and
The University of Utah
Address:
Academy of Sciences of the Czech Republic
P.M.M. Secretariat
Heyrovského nám. 2
162 06 Praha 6, Czech Republic
Phone: +420-2-204 03 332
Fax: +420-2-36 79 81
E-mail: sympo@imc.cas.cz
International Advisory Board
| J.M. Anderson (U.S.A.) | T. Kissel (Germany) |
| R. Duncan (U.K.) | J.B. Lloyd (U.K.) |
| R. Gurny (Switzerland) | T. Nagai (Japan) |
| J. Heller (U.S.A.) | S. Penczek (Poland) |
| J. Jozefonvicz (France) | N.A. Platé (Russia) |
| M. Jozefowicz (France) | H. Ringsdorf (Germany) |
| S.W. Kim (U.S.A.) | E.H. Schacht (Belgium) |
Honorary Microsymposium Chairman
Jindřich Kopeček (U.S.A.)
Microsymposium Chairman
Karel Ulbrich
Local Programme Committee
V. Chytrý,
J. Michálek, M. Pechar, F. Rypáček, B. Říhová,
K. Smetana, V. Šubr, J. Vacík
The meeting has been generously sponsored by
On-site registration of participants takes place on Sunday, 16 July, from 14:00 to 21:00 in the Komenský hall of residence, Praha 6, Parléřova 6; the registration continues in the Institute of Macromolecular Chemistry (Room C) the next day. The Microsymposium Office will operate on 17 – 20 July (Monday through Thursday) from 08:30 to 12:30 and from 13:30 to 16:30.
All participants must register. Only persons wearing name badges are entitled to enter the lecture room.
No exchange counter operates in the Komenský hall of residence or in the Institute of Macromolecular Chemistry. Information about the nearest exchange office is available at the Registration Desk.
On-site cash payment of the registration fee is considered as payment after 15 April. The P.M.M. Secretariat is able to accept embossed EC/MC and VISA cards at the Registration Desk.
The registration fee does not include provisions for any kind of insurance. Neither the organizing institutions nor their representatives assume responsibility or liability for personal accident and loss of or damage to belongings however caused.
Accommodation for most participants has been reserved in the Komenský hall of residence, Praha 6, Parléřova 6 and in the Kajetánka hall of residence, Praha 6, Radimova 12. Cash payment of the booked accommodation is to be made at the Registration Desk.
The main lecturers are accommodated in the Academy residence "Villa Lanna", Praha 6 , V sadech 1.
Accommodation includes breakfast. Breakfast will be served in the cafeteria of all the mentioned houses from 07:00 to 08:00.
Participants must leave the rooms on the day of their departure by 12:00.
In Prague, an integrated transport system (underground Metro, trams, and buses) operates without conductors. Tickets must be purchased in advance (exceptions given below) and stamped inside tram or bus, or before passing the gates of the Metro.
Most Metro stations are equipped with ticket machines. In buses, the most common 60-min tickets can be bought at the driver, but with additional charge of 3 Kč and in coins counted out in advance. Tickets for 8 Kč for a single 15-minute journey by tram or bus, or four-stop journey by Metro as well as transfer tickets for 12 Kč for a 60-minute journey (90 min at night and on weekends) by all means of transport are on sale at the airport, at railway stations, newspaper stands and tobacco shops, at hotel reception desks, in restaurants, etc. The Metro runs from 05:00 till midnight.
From the Komenský hall of residence, go 200 m downhill to the "Hládkov" tram stop and take tram No 8 (in the direction "Nádraží Vysočany"), in July also tram No 22 or 23. Get off at the next stop ("Vozovna Střešovice") and change for tram No 1, 2, or 18 (in the opposite direction, Petřiny) as far as the terminus PETŘINY. (connection suitable for getting to the Institute to morning sessions is listed in separate document)
From the Kajetánka hall of residence, take any of buses No 108, 174, 180 downhill (direction Špejchar or Kafkova) to the "Vozovna Střešovice" stop (2 stops) and change for tram No 1, 2, or 18 (in the opposite direction Petřiny) as far as the terminus PETŘINY. (connection suitable for getting to the Institute to morning sessions is listed in separate document)
From the Academy residence, walk uphill along the Pelléova street to the Pod kaštany street (2nd crossing), turn 45° right to the Pod kaštany street and continue to the subway of "Hradčanská" metro station. Take tram No 1 or 18 (in the direction, PETŘINY) as far as the terminus PETŘINY.
From the city centre, take the Metro green line A as far as the "Hradčanská" station. From there, take tram No 1 or 18 (in the direction PETŘINY) as far as the terminus PETŘINY.
From the Institute, take tram No 1, 2, or 18 and get off at "Vozovna Střešovice" (7 stops), change for tram No 8 (in the opposite direction, BÍLÁ HORA), in July also No 22 or 23, get off at the next stop ("Hládkov"), and go forward to the Parléřova Street. You can also use from "Vozovna Střešovice" any of buses No 108, 174, 180, 217 to the next stop ("Hládkov") and come over pedestrian bridge directly to the hall of residence. Another way is to leave tram No 1, 2, or 18 at "Sibeliova" (6 stops), turn right and after 100 m go downstairs to the "Hládkov" tram stop and proceed as above.
From the city centre, take the Metro green line A and go to the "Hradčanská" station. From there, take tram No 8 (in the direction BÍLÁ HORA), get off at "Hládkov" (3 stops), and go forward to the Parléřova Street. From the city centre you may also take direct lines by tram No 22 or 23, get off at "Hládkov", and proceed as above.
From the Institute, take any tram (1,2,18) to the "Vozovna Střešovice" stop (7 stops), and change for any of buses 108, 174, 180 (in the opposite direction) to the "Kajetánka" stop (2 stops).
From the Institute, take tram No 1 or 18, get off at "Hradčanská" (9 stops), immediately after entering subway turn right and continue to the most remote exit. From here, walk 300 m through Pod Kaštany Street, then turn 45° left to Pelléova Street and continue another 300 m to the residence.
From the city centre, take the Metro green line A to "Hradčanská" station. Leaving escalator turn left and proceed as above.
From the Institute, follow the route to the Větrník refectory. Behind the refectory, continue along Na Větrníku street eastward to the next crossing (with Myslivečkova street, 200 m) and turn right to the abbey garden and go straight on down to the abbey.
From the city centre or from Komenský hall of residence, take tram No 8 or 22 (in the direction BÍLÁ HORA) to the "Břevnovský klášter" stop (5 stops from "Hládkov"). The abbey can be seen from the stop.
From Kajetánka hall of residence, the abbey can be seen westward (about 15-min walk). Nevertheless, you can also take bus No 108, 174 or 180 (1 stop uphill).
The taxi fare is 22 Kč per kilometre and 30 Kč the boarding fee within the city boundaries. The special taxi fare from the Komenský hall of residence or from the Institute to the airport is Kč 600-700 Kč.
We recommend negotiating the fare before entering a cab and asking for a bill before payment. (Be careful with taxis.)
A special bus will bring the participants from the Academy residence to the Institute only in the morning; the departure times are given on the notice board at the Registration Desk. The bus will also bring them to the concert on Monday (departure from the Academy residence at 19:30).
Prague has direct air links with most capitals in Europe and with many overseas countries. The international airport Praha is situated about 20 km from the city centre. Of buses in service at the airport, we recommend bus No 179 for reaching the Institute and bus No 119 for connection to the Metro station "Dejvická" (line A). Bus fare: 12 Kč.
Buses operated by the CEDAZ Co. run from the airport to the city terminal near the Metro station "Náměstí Republiky" (line B) in 30-min intervals. Bus fare: 90 Kč.
International trains leave Prague from the following stations: Praha, hlavní nádraží (Main Station; Metro line C), Praha – Holešovice (Metro line C), and Praha – Smíchov (Metro line B).
Coffee, tea, and soft drinks will be available during the breaks of the programme sessions.
Lunch will be served from Monday through Thursday (12:30-13:30) to active participants and registered accompanying persons (except for Tuesday to the latter) in the refectory of the hall of residence "Větrník" in walking distance from the Institute. Admission by tickets (L1 – L4) only.
Refreshments and lunch are included in the registration fee.
Sunday, 16 July, 19:00-21:00. All registered participants are cordially invited to take part in a complimentary get-together party with cold dishes in the Komenský hall of residence.
Monday, 17 July, 20:00. Piano concert at the Theresian Hall of the Benedictine archabbey of St. Adalbert and St. Margaret in Břevnov.
Wednesday, July 19, 14:00-23:00. Visit to the château Kozel, originally hunter's lodge situated in a large landscaped park. The excursion continues in Plzeň, city famous for its brewery and heavy machinery Škoda. Visit to the unique Brewery museum. The informal dinner will be served in the Pilsner Urquell restaurant.
The bus departs from the Institute at 14:00 and returns to the Academy residence, Komenský hall of residence and Kajetánka hall of residence. Admission by tickets ("Excursion") only.
Price: CHF 90.
Thursday, 20 July: After the last lecture, all participants are invited to a farewell drink in the entrance hall of the Institute.
Admission only to the registered persons (including children) who paid the fee. The fee includes four lunches, three of which (on Monday, Wednesday, and Thursday) are served in the refectory of the halls of residence "Větrník" from 12:30 to 13:30 (see p. 9). Please, present your tickets when entering the bus ("Accompanying Persons Programme") or the refectory (AP L1 – AP L4).
14:00-17:00 – Introductory sightseeing in Prague.
The bus departs from the Institute and returns to the Academy residence, Komenský hall of residence and Kajetánka hall of residence.
09:00-17:00 – Visit to glassworks Nižbor producing hand-cut lead crystal. Visit to the medieval castle Křivoklát, 50 km west of Prague which used to be a seat of rulers of Bohemia from the Přemyslid dynasty (until 1306) and of kings of the Luxemburgh (1310 –1437) and Jagiello (1471-1526) dynasties. Lunch in a restaurant in the vicinity of the castle.
The bus departs from the Institute and returns to the Academy residence, Komenský hall of residence and Kajetánka hall of residence.
09:00-12:30 – Guided visit to the Prague Castle (Hradčany).
The bus departs from the Institute. After a walk through the Castle area and to "Malostranské náměstí" (Lesser-Town Square), the bus returns to the halls of residence "Větrník".
09:00-12:30 – Guided tour including a walk over the Gothic Charles Bridge (Karlův most), often called "the gallery of statues in the open air", and through the Old Town of Prague.
The bus departs from the Institute, and returns to the halls of residence "Větrník".
All sessions will be held in the Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic, Praha 6 – Petřiny, Heyrovského náměstí 2.
English is the working language of the Microsymposium. No translation will be provided.
The presentation time for each lecture is 40 minutes, including discussion.
The presentation time for each lecture is 30 minutes, including discussion.
Poster sessions will take place on Tuesday and Wednesday, always in the morning. Posters should be mounted the day preceding the corresponding session to make them freely accessible to the participants, and removed till the Tuesday or Thursday afternoon.
Blackboard, projector of 5 x 5 cm slides (the slide projector will not function with slides thicker than 2.5 mm), overhead projector, and videoprojector (XGA) with the possibility of connecting to a notebook, to local PC (ZIP, CD, FDD 3.5) or to VHS are available for lectures and discussions; The speakers are requested to bring their slides to the operator during the break before the session. Boards for mounting posters as well as pushpins and felt-tip pens are available in the poster area.
Both main lectures and special lectures will be published in a special volume of Macromolecular Symposia.
| ML 1 | K. Ulbrich,
V. Šubr, M. Pechar, D. Plocová, J. Strohalm, T. Etrych,
M. Jelínková, M. Kovář, B. Říhová (Czech Republic) Antibody-targeted Polymer Carriers of Drugs |
| ML 2 | S.W. Kim (U.S.A.) Novel Functional Polymers for Gene Delivery |
| ML 3 | K. Kataoka (Japan) Tailor-made Block Copolymer Micelles and Nanoparticles for Drug Delivery |
| ML 4 | R. Zeeman,
L.D.D. Olde Damink, M. Hendriks, P.T. Cahalan, P.B. van
Wachem, L.A. Brouwer, M.J.A. van Luyn, M.J.B. Wissink,
G.H.M. Engbers, W.G. van Aken, A.A. Poot, P.J. Dijkstra, J.
Feijen, (Netherlands) Collagen-based Biomaterials |
| ML 5 | T. Okano,
J. E. Chung, M. Yokoyama (Japan) Temperature-responsive Intelligent Polymers for Targeted Drug Delivery |
| ML 6 | D. A. Tirrell
(U.S.A.) Engineering Molecular and Cellular Recognition in Artificial Proteins |
| ML 7 | R. Duncan,
S. Richardson, N. Pattrick(U.K.), P. Ferruti (Italy) Synthetic Vectors for Intracytoplasmic Delivery |
| ML 8 | J.A. Hubbell
(Switzerland) Degradable and Resorbable Hydrogels for Local Delivery and Modulation of Biological Responses |
| H. Ringsdorf
(Germany) Bioinspired Polymers: Where East Meets West and North Meets South (special opening lecture) |
|
| SL 1 | V.R. Caiolfa,
M. Farao, E. Frigerio A, C. Pellizzoni A, M. Zamai,
E. Pesenti, A. Suarato (Italy) Pharmacological Profile of HPMA-Copolymers of Camptothecin |
| SL 2 | B. Říhová, J. Strohalm, M.
Jelínková, O. Hovorka, M. Kovář, D. Plocová, M. Šírová,
M. Šťastný, K. Ulbrich (Czech
Republic) Immunoprotective Therapy with Targeted Anticancer Drugs |
| SL 3 | J.B. Lloyd (United
Kingdom) The Lysosome/Endosome Membrane: A Barrier to Polymer-based Drug Delivery? |
| SL 4 | T. Minko, P. Kopečková, J. Kopeček
(U.S.A.) Mechanism of Anticancer Action of HPMA Copolymer-bound Doxorubicin |
| SL 5 | A.S.
Hoffman, C. Cheung, C. Lackey, N. Murthy, P. Stayton,
T. Kyriakides, P. Bornstein, N. Fausto, J. Campbell, O.
Press (U.S.A.) Design of Synthetic Polymers to Enhance Intracellular Trafficking of DNA |
| SL 6 | J.P.
Kennedy, G. Fenyvesi, R.P. Levy, K.S. Rosenthal (U.S.A.) Designed Rubbery Polymers for Biomaterial Applications |
| SL 7 | N.A. Platé, L.I.
Valuev (Russia) Novel Aspects of Oral Drug Delivery through Polymeric Hydrogels |
| SL 8 | J.M. Anderson
(U.S.A.) Biomedical Polymer Modulation of Macrophage and Foreign Body Giant Cell Adhesion and Function |
| SL 9 | A.
Rothen-Weinhold, J. Barr, S.Y. Ng, H.-R. Shen, R. Gurny, J.
Heller (U.S.A.) Protein Release from Poly(ortho ester)-extruded Rods |
| SL 10 | S. Einmahl
(Switzerland), F. Behar-Cohen (France),
C. Tabatabay, R. Gurny (Switzerland) Treatment of Intraocular Diseases With Poly(ortho ester)-based Drug Delivery Systems |
| SL 11 | C. Gervelas,
T. Avramoglou, J. Jozefonvicz, M. Jozefowicz (France) Tailor-made Biomimetic Random Copolymers for Medical Applications |
| SL 12 | J.J. Kim, K.
Park, (U.S.A.) Modulated Insulin Delivery Using Phase-reversible Glucose-sensitive Hydrogels |
| SL 13 | A.V.
Kabanov, E.V. Batrakova, S. Li, V. Yu. Alakhov (U.S.A.) Selective Energy Depletion and Sensitization of Multiple Drug Resistant Cancer Cells by Pluronic Block Copolymers |
| SL 14 | T. Kissel,
T. Jung, A. Breitenbach, W. Kamm (Germany) Biodegradable Graft Polyesters Based on Poly(lactide-co-glycolide) and PVAL for Oral Vaccine Delivery |
| SL 15 | R.M.
Ottenbrite, R. Zhao, M. Haratake (U.S.A.) Oligopeptides as Potential Insulin Drug Delivery System |
| SL 16 | E. Neuse (South
Africa) Polymeric Organoiron Compounds as Pro-drugs in Cancer Research |
| SL 17 | D. Oupický (Czech
Republic), K.D. Fisher, Y. Stallwood, M. Ogris,
V. Mautner, L.W. Seymour (United Kingdom) Polymer-based Systems for Site Specific Gene Delivery and Transfection |
| SL 18 | D. Putnam,
C. Gentry, R. Langer (U.S.A.) Design and Synthesis of High Efficiency Synthetic Gene Delivery Systems |
| SL 19 | P.-Y. Yeh,
P.L. Smith (U.S.A.) Physiological Considerations in Dosage Form Design |
| SL 20 | T. Hirano,
T.Kondo, T.Todoroki, S.Ohashi (Japan) Design of the Conjugate of Superoxide Dismutase (SOD) with the Copolymer of Divinyl Ether and Maleic Anhydride as an Anti-inflammatory Agent |
| SL 21 | Y.H. Bae,
S.I. Kang, K. Na (Korea) Sulfonamide-containing Polymers: A New Class of pH-sensitive Polymers and Gels |
| Sunday | 14:00-21:00 | Registration | |
| 16 JULY | 19:00 – 21:00 | Welcome reception | |
| Monday | 09:00 – 09:25 | Opening ceremony | |
| 17 JULY | 09:25 – 09:55 | Opening
lecture H. Ringsdorf (Germany) |
|
| 09:55 – 10:35 | K. Ulbrich (Czech Republic) | ML 1 | |
| 10:35 – 11:05 | Coffee break | ||
| 11:05 – 11:35 | A. Suarato (Italy) | SL 1 | |
| 11:35 – 12:15 | S.W. Kim (U.S.A.) | ML 2 | |
| 12:15 – 14:00 | Lunch | ||
| 14:00 – 14:30 | B. Říhová (Czech Republic) | SL 2 | |
| 14:30 – 15:00 | J.B. Lloyd (U.K.) | SL 3 | |
| 15:00 – 15:30 | T. Minko (U.S.A.) | SL 4 | |
| 15:30 – 16:00 | Coffee break | ||
| 16:00 – 16:40 | K. Kataoka (Japan) | ML 3 | |
| 16:40 – 17:10 | A.S. Hoffman (U.S.A.) | SL 5 | |
| 17:10 – 17:40 | J.P. Kennedy (U.S.A) | SL 6 | |
| 20:00 | Concert | ||
| Tuesday | 08:30 – 09:10 | J. Feijen (Netherlands) | ML 4 |
| 18 JULY | 09:10 – 09:40 | L.I. Valuev (Russia) | SL 7 |
| 09:40 – 10:10 | J.M. Anderson (U.S.A.) | SL 8 | |
| 10:10 – 10:40 | J. Heller (U.S.A.) | SL 9 | |
| 10:40 – 11:00 | Coffee break | ||
| 11:00 – 12:15 | Poster session I | PS 1 | |
| 12:15 – 14:00 | Lunch | ||
| 14:00 – 14:40 | T. Okano (Japan) | ML 5 | |
| 14:40. 15:10 | S. Einmahl (Switzerland) | SL 10 | |
| 15:10 – 15:40 | M. Jozefowicz (France) | SL 11 | |
| 15:40 – 16:10 | Coffee break | ||
| 16:10 – 16:40 | K. Park (U.S.A.) | SL 12 | |
| 16:40 – 17:10 | A.V. Kabanov (U.S.A.) | SL 13 | |
| 17:10 – 17:40 | T. Kissel (Germany) | SL 14 | |
| Wednesday | 08:30 – 09:10 | D.A. Tirrell (U.S.A.) | ML 6 |
| 19 JULY | 09:10 – 09:40 | R.M. Ottenbrite (U.S.A.) | SL 15 |
| 09:40 – 10:10 | E. Neuse (South Africa) | SL 16 | |
| 10:10 – 10:40 | L.W. Seymour (U.K.) | SL 17 | |
| 10:40 – 11:00 | Coffee break | ||
| 11:00 – 12:15 | Poster session 2 | PS 2 | |
| 12:15 – 14:00 | Lunch | ||
| 14:00 – 23:00 | Excursion & Informal dinner | ||
| Thursday 20 JULY |
09:00 – 10:10 | Panel
discussion Discussion leader J.D. Andrade (U.S.A.) |
PD |
| 10:10– 10:40 | D. Putnam (U.S.A.) | SL18 | |
| 10:40 – 11:05 | Coffee break | ||
| 11:05 – 11:45 | R. Duncan (U.K.) | ML 7 | |
| 11:45 – 12:15 | P.-Y. Yeh (U.S.A) | SL 19 | |
| 12:15 – 14:00 | Lunch | ||
| 14:00 – 14:40 | J. A. Hubbell (Switzerland) | ML 8 | |
| 14:40 – 15:10 | T. Hirano (Japan) | SL 20 | |
| 15:10 – 15:40 | Y.H. Bae (Korea) | SL 21 | |
| 15:40 | J. Kopeček (U.S.A.) | Closing remarks | |
| Farewell |
Monday Tuesday Wednesday Thursday
| 09:00 | opening
ceremony Opening addresses: K. Ulbrich J.W. Mauger P. Kratochvíl |
|
| 09:25 | Lecture session 1 | Chairpersons:
J.D. Andrade (U.S.A.) B. Říhová (Czech Republic) |
| 09:25 | Opening
lecture H. Ringsdorf (Germany) |
|
| 9:55 | Main
lecture ML 1 K. Ulbrich, V. Šubr, M. Pechar, D.
Plocová, J. Strohalm, T. Etrych, M. Jelínková, M.
Kovář, B. Říhová (Czech
Republic) |
|
| 11:05 | Special
lecture SL 1 V.R. Caiolfa, M. Farao, E. Frigerio, A.C. Pellizzoni, A.M. Zamai, E. Pesenti, A. Suarato (Italy) Pharmacological Profile of HPMA-Copolymers of Camptothecin |
|
| 11:35 | Main
lecture ML 2 S.W. Kim (U.S.A.) |
|
| 14:00 | Lecture session 2 | Chairpersons:
H. Ringsdorf (Germany) J. Vacík (Czech Republic) |
| 14:00 | Special
lecture SL 2 B. Říhová, J. Strohalm,
M. Jelínková, O. Hovorka, M. Kovář, D. Plocová,
M. Šírová, M. Šťastný, K. Ulbrich (Czech Republic) |
|
| 14:30 | Special
lecture SL 3 J.B. Lloyd (U.K.) |
|
| 15:00 | Special
lecture SL 4 T. Minko, P. Kopečková, J. Kopeček
(U.S.A.) |
|
| 16:00 | Lecture session 3 | Chairpersons:
J.M. Anderson (U.S.A.) F. Rypáček (Czech Republic) |
| 16:00 | Main
lecture ML 3 K. Kataoka (Japan) |
|
| 16:40 | Special
lecture SL 5 A.S. Hoffman,
C. Cheung, C. Lackey, N. Murthy, P. Stayton, T.
Kyriakides, P. Bornstein, N. Fausto, J. Campbell, O.
Press (U.S.A.) |
|
| 17:10 | Special
leture SL 6 J.P. Kennedy,
G. Fenyvesi, R.P. Levy, K.S. Rosenthal (U.S.A.) |
|
| 08:30 | LECTURE SESSION 4 | Chairpersons:
J.B. Lloyd (U.K.) M. Houska (Czech Republic) |
| 08:30 | Main
lecture ML 4 R. Zeeman,
L.D.D. Olde Damink, M. Hendriks, P.T. Cahalan, P.B. van
Wachem, L.A. Brouwer, M.J.A. van Luyn, M.J.B. Wissink,
G.H.M. Engbers, W.G. van Aken, A.A. Poot, P.J. Dijkstra, J.
Feijen, (Netherlands) |
|
| 09:10 | Special
lecture SL 7 N.A. Platé, L.I.
Valuev (Russia) |
|
| 09:40 | Special
lecture SL 8 J.M. Anderson (U.S.A.) |
|
| 10:10 | Special
lecture SL 9 A.
Rothen-Weinhold, J. Barr, S.Y. Ng, H.-R. Shen, R. Gurny, J.
Heller (U.S.A.) |
|
| 11:00 |
Poster Session: PS 1 |
|
| P 1 | P. Peterková, L. Lapčík, Jr. Biocompatibilization of Poly(propylene) Based Wrapping Materials |
|
| P 2 | L. Toman, P. Vlček, J. Michálek,
J. Vacík, K. Smetana, B. Dvořánková, J. Spěváček,
P. Holler, I. Kelnar Utilization of Multifunctionalized Polyisobutylene as Building Blocks for the Synthesis of Polymer Networks for Biomedical Applications |
|
| P 3 | R.
Rozhnova, N. Galatenko Biodegraded Implants with Drug Action |
|
| P 4 | Č. Koňák, B. Gantchev, S.M.
Teodorescu, K. Matyjaszewski, P. Kopečková, J. Kopeček Micelles of Poly[N-(2-hydroxypropyl)methacrylamide-block-butyl acrylate] in Water/Dimethylformamide Mixed Solvents |
|
| P 5 | J. Lukáš, V. Palečková, J.
Mokrý, J. Karbanová, B. Dvořánková Hydrogels for Encapsulation of Cells: Characterization and Application in Encapsulation of Dopamin-producing Cells |
| P 6 | M.
Grigorjeva, I. Gladir, N. Galatenko The Polyurethane Systems as Drug Carriers: Kinetic Models |
| P 7 | D. Neradovic,
W.L.J. Hinrichs, J.J. Kettenes-Van Den Bosch, C.F. Van
Nostrum, W.E. Hennink Poly(N-isopropylacrylamide) with Hydrolyzable Lactic Acid Ester Side Groups: A New Type of Thermosensitive Polymer Suitable for Drug Delivery Purposes |
| P 8 | H. Drnovská, L. Lapčík Hyaluronate as a Tool for Modification of the Viscoelastic Properties in Connective Tissue Matrix |
| P 9 | D.D. N`Da,
M.G. Meirim, E.W. Neuse, W.-C. Shen Polymer Conjugates Comprising the Antiproliferative Ferrocene System Carrier-Bound via Ester Links |
| P 10 | P. Kuzma,
A.J. Moo-Young, I.M. Spitz, H. Quandt, T. Lindenberg, B.
Chertin, A. Farkas, J. Frick, P. Schlegel HydronTM Implant for Continuous Treatment of Prostate Cancer: Twelve Months and Beyond |
| P 11 | F. Tajarobi,
M. El-Sayed, B. Rege, J. Polli, H. Ghandehari Transport of Poly(amidoamine) (PAMAM) Dendrimers across Madin-Darby Canine Kidney (MDCK) Cell Lines |
| P 12 | N. Mphephu,
M.G. Meirim, E. W. Neuse, W.C. Shen Water-Soluble Conjugates Featuring Platinum Complexes Carrier-Bound through cis-Dihydroxylatometal Chelation |
| P 13 | D. Oupický,
L.W. Seymour Improved Pharmacokinetics of Poly-L-Lysine/DNA Complexes Stabilised with Intracellularly Cleavable Surface Crosslinking |
| P 14 | M. Yokoyama,
M. Kurisawa, T. Okano Gene Expression Control by Temperature |
| P 15 | L.I. Dahms,
K. Lützow, W. Albrecht, D. Paul, G. Kossmehl Preparation of Bioconjugates and Covalent Binding to Polymers |
| P 16 | M. El-Sayed,
M. F. Kiani, M. D. Naimark, H. Ghandehari Influence of Polymeric Structural Features on the Transport of Poly(amidoamine) Dendrimers across Biological Barriers |
| P 17 | A. David, P. Kopečková, A.
Rubinstein, J. Kopeček Targetable HPMA Copolymer Conjugates: Biorecognition, Internalization and Cytotoxicity in Colon-Adenocarcinoma and Hepatocarcinoma Cells |
| P 18 | A.A.A. De
Queiroz, H.G. Ferraz, G.A. Abraham, J. San Román Development of Hydroactive Dressing Based on Chitosan Membranes |
| P 19 | M. Kissel, P.
Peschke, V. Šubr, K. Ulbrich, E. Friedrich, J. Debus Uptake of Poly[N-(2-hydroxypropyl)methacrylamide] in Organs and its Cellular Detection in Tumor-bearing Rats |
| P 20 | Y. Tang, J.R.
Lu, A. Lewis, T. Vick Water Diffusion in Biocompatible PC Polymer Films |
| P 21 | A.-M.
Balazuc, M. Lagranderie, G. Marchal, V. Coessens, E.
Roseeuw, E. Schacht, D. Domurado Vectorized Norfloxacin is Effective in Vivo against Mycobacteria |
| P 22 | M. Kulikova,
M. Berkovich, A. Abramson, V. Naumov Adsorption of Poly(vinyl acetal)s on the Submerged Interface |
| P 23 | E.A.
Markvicheva, G.B. Sukhorukov, S.V. Kuptsova, A.A. Vikhrov Encapsulation of Proteins and DNA Using Layer-by-layer Adsorption: Method and Applications |
| P 24 | T.G. Park Doxorubicin Conjugated Biodegradable Polymeric Micelles and Nanoparticles for Cancer Therapy |
| P 25 | J. Souček, P. Poučková, D. Hloušková,
M. Zadinová, Z. Hrkal, D. Plocová, J. Strohalm, K.
Ulbrich Specific Antitumor Activity of Poly[N-(2-hydroxypropyl)methacrylamide] Conjugated Bovine Seminal Ribonuclease |
| P 26 | S. Strandman,
A. Koskelainen, H. Tenhu Crown Ether-substituted Water-soluble Graft Copolymers |
| P 27 | V.A.
Izumrudov, V.I. Muronetz, M.B. Dainiak, I. Yu. Galaev, Bo
Mattiasson Production of Fab Fragments of Monoclonal Antibodies With the Use of Synthetic Polyelectrolytes |
| P 28 | V.A.
Izumrudov, M.V. Zhiryakova General Principles of Creating of DNA-containing Polyelectrolyte Complexes with Controllable Stability |
| P 29 | S.
Farè, P. Petrini, M.C. Tanzi Effects of Aging under Dynamic Conditions in Physiological-like Environments on the Mechanical Behavior of Medical Grade Polyurethanes |
||
| P 30 | P.
Petrini, S. Farè, M.C. Tanzi Designing Polyurethanes for Biomedical Devices, Tissue Engineering and Drug Release |
||
| 14:00 | LECTURE SESSION 5 | Chairpersons:
G. Wilson (U.S.A.) E. Syková (Czech Republic) |
|
| 14:00 | Main
lecture ML 5 T. Okano,
J. E. Chung, M. Yokoyama (Japan) |
||
| 14:40 | Special
lecture SL 10 S. Einmahl (switzerland),
F. Behar-Cohen (France), C. Tabatabay, R, Gurny (Switzerland) |
||
| 15:10 | Special
lecture SL 11 C. Gervelas, T.
Avramoglou, J. Jozefonvicz, M. Jozefowicz (France) |
||
| 16:10 | LECTURE SESSION 6 | Chairpersons:
R. Duncan (U.K.) V. Šubr (Czech Republic) |
|
| 16:10 | Special
lecture SL 12 J.J. Kim, K.
Park, (U.S.A.) |
||
| 16:40 | Special
lecture SL 13 A.V. Kabanov,
E.V. Batrakova, S. Li, V.Yu. Alakhov (U.S.A.) |
||
| 17:10 | Special
lecture SL 14 T. Kissel,
T. Jung, A. Breitenbach, W. Kamm (Germany) |
||
| 08:30 | LECTURE SESSION 7 | Chairpersons:
T. Kissel (Germany) J. Lukáš (Czech Republic) |
| 08:30 | Main
lecture ML 6 D.A. Tirrell (U.S.A.) |
|
| 09:10 | Special
lecture SL 15 R.M.
Ottenbrite, R. Zhao, M. Haratake (U.S.A.) |
|
| 09:40 | Special
lecture SL 16 E. Neuse (South
Africa) |
|
| 10:10 | Special
lecture SL 17 D. Oupický (Czech
Republic) K.D. Fisher, Y. Stallwood, M. Ogris, V.
Mautner, L.W. Seymour (U.K.) |
|
| 11:00 | Poster Session: PS 2 | |
| P 31 | M.
El Fray, P. Prowans Studies on Multiblock Poly(ester-ester)s for Biomedical Applications: Experimental Studies in Rats |
|
| P 32 | T. Reschel, K. Ulbrich, Č. Koňák,
D. Oupický, L. Seymour Synthetic Polymers for Delivery of Genes |
|
| P 33 | L.
Vargová, Š. Kubinová, L. Tao, K. Ulbrich, V. Šubr, C.
Nicholson, E. Syková Diffusion of PHPMA Polymers in Brain Extracellular Space |
|
| P 34 | E.W.
Neuse, M.G. Meirim, H.M. Netshifhefhe, W.-C. Shen Antiproliferative Monoamine-Coordinated Platinum Complexes Conjugated to Water-Soluble Carrier Polymers |
|
| P 35 | E.
Brynda, M. Houska, A. Wikerstal, A. Brandenburg Interaction of Blood Plasma with Immobilized Protein Assemblies |
|
| P 36 | Z.
Mustafaeva, M. Demchenko, E. Ergen, A. S. Dilgimen, M.
Mustafaev Immunogenic Ecity of Amphiphilic Water Soluble Conjugates of Serum Proteins with Temperature-sensitive Poly(N-isopropylacrylamide) |
|
| P 37 | I.
Lacík, T.G. Wang, A.V. Anilkumar Design of Microcapsule for Encapsulation of Living Cells Based on Polyelectrolyte Complexation Role of the Anti-Gelling Cation |
|
| P 38 | T.
Etrych, K. Ulbrich, M. Jelínková, B. Říhová Polymer and Polymer-Antibody Conjugates With Hydrazone-attached Doxorubicin |
|
| P 39 | M.
Pechar, A. Braunová, K. Ulbrich Poly(ethylene glycol) Multiblock Copolymers Containing Ester Bonds as Biodegradable Water-Soluble Carriers of Drugs |
|
| P 40 | H.
Mazi, B. Zümreoglu-Karan, A. Güner Dextran-Rare Earth Ion Dynamics in Aqueous Solutions |
|
| P 41 | H.
Kaplan Can, A. Güner, Z.M.O. Rzaev Characterization of g -Ray Induced Povidone and Povidone/Persulfate Systems |
|
| P 42 | Z.M.O. Rzaev, A. Güner, H. Kaplan
Can, Ő. Akman, B. Kirci Synthesis and Properties of Some Selective Cl-, P- and N-containing Dextran Hydrogels |
|
| P 43 | V.
Šubr, T. Etrych, K. Ulbrich, T. Hirano, T. Kondo, T.
Todoroki Polymer Conjugates of Superoxide Dismutase |
|
| P 44 | P.
Ferruti, R. Mendichi, M. Casolaro, S.C.W. Richardson,
N.G. Pattrick, R. Duncan Amphoteric Poly(amido-amine)s as Endosomolytic Polymers |
|
| P 45 | M. Šírová, M. Jelínková, M.
Kovář, P. Rossmann. K. Ulbrich, B. Říhová Natural Killer Cell Activity in Tumor-Bearing Mice Treated with Doxorubicin and HPMA-Bound Doxorubicin (PK1) |
|
| P 46 | M. Šťastný, J. Strohalm, M.
Kovář, D. Plocová, K. Ulbrich, B. Říhová HPMA Hydrogels Containing Different Anticancer Drugs and their Efficacy in the Treatment of B-Cell Leukemia |
|
| P 47 | M. Kovář, J. Strohalm, K.
Ulbrich, B. Říhová Modification of Two Different Anti-CD71 Monoclonal Antibodies with Poly(HPMA) Carrier Produces Inverse Effect |
|
| P 48 | M. Jelínková, K. Ulbrich, J.
Strohalm, T. Etrych, B. Říhová "Star-like" Macromolecular Prodrugs |
|
| P 49 | M.
Gorshkova, L. Stotskaya, E.Pecherskikh Immunological Features of Macromolecular Prodrug for Controlled Release of Anthracycline Antibiotic |
|
| P 50 | B.
Rittich, J. Lenfeld, A. Španová, I. Marková, Yu.
Ohlashenyy, M.J. Beneš Study of Activity of DNASE I Immobilized on Magnetic Cellulose |
|
| P 51 | V.
Chytrý, K. Ulbrich Temperature-responsive Polymer Bound Doxorubicin |
|
| P 52 | P.
Bureš, N.A. Peppas A New Dispersion Technique for Micro- and Nanoparticle Formation of Drug Delivery Carriers Based on Poly(acrylic acid) |
|
| P 53 | J.
Vacík, K. Smetana, Jr., B. Dvořánková, J. Michálek, J.
Labský, L. Brož Polymeric Support for Cultivation and Transfer of Skin Cells |
|
| P 54 | M.G.
Meirim, D.D. N`Da, E.W. Neuse, W.-C.Shen, C.J.E. van
Rensburg Anticancer Prodrugs Based on Poly(aspartamide)-conjugated Methotrexate |
|
| P 55 | C.
Wang, R.J.
Stewart, J. Kopeček Novel Design of Smart Hydrogels from Synthetic and Genetically Engineered Polymers |
|
| P 56 | A.
De Simone, C. Hunter, A. J. Ryan, S. MacNeil PEG-Peptide Block Copolymers for Fabrication of Synthetic Skin |
|
| P 57 | H.M.
Netshifhefhe, N. Mphephu, M.T. Johnson, E. W. Neuse Dicarboxyl-functionalized Carrier Polymers as Precursors of Macromolecular Platinum Drugs |
|
| P 58 | F.
Tajarobi, M. El-Sayed, B. Rege, J. Polli, H. Ghandehari Transport of Poly(amidoamine) (PAMAM) Dendrimers across Madin-Darby Canine Kidney (MDCK) Cell Lines |
|
Supplement:
| P 59 | J. Labský, J. Vacík, P. Hošek Polymer bond scavenegers-the breaktrough in wound healing |
| P 60, 61, 62 | J. Andrade Beyond the Mono-Parameter Paradigm -- Looking at the Whole Elephant |
| 09:00 | PANEL DISCUSSION | |
| The
Future of Biomedical Polymers Invited discussion leader: J.D. Andrade (U.S.A.) |
||
| 10:10 | LECTURE SESSION 8 | Chairpersons:
A. Rubinstein (Israel) E. Brynda (Czech Republic) |
| 10:10 | Special
lecture SL 18 D. Putnam,
C. Gentry, R. Langer (U.S.A.) |
|
| 11:05 | Main
lecture ML 7 R. Duncan,
S. Richardson, N. Pattrick (U.K), P. Ferruti (Italy) |
|
| 11:45 | Special lecture SL 19P.-Y. Yeh, P.L. Smith (U.S.A.) |
|
| 14:00 | LECTURE SESSION 9 | Chairpersons:
S.W. Kim (U.S.A.) D. Oupický (Czech Republic) |
| 14:00 | Main
lecture ML 8 J.A. Hubbell (Switzerland) |
|
| 14:40 | Special
lecture SL 20 T. Hirano,
T.Kondo, T.Todoroki, S.Ohashi (Japan) |
|
| 15:10 | Special lecture SL 21Y.H. Bae, S.I. Kang, K. Na (Korea) |
|
| 15:40 | CLOSING REMARKS | |
Items included in the supplement are in italics
Supplement:
Supplement: