Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation

Svetlana Lukáš Petrova; Ewa Pavlova; Václav Pokorný; Vladimir Sincari

doi:10.1039/D3NA01038D

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Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation†

Svetlana Lukáš Petrova,

*^a Ewa Pavlova,^a Václav Pokorný^a and Vladimir Sincari

*^a

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* Corresponding authors

^a Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic
E-mail: petrova@imc.cas.cz

Abstract

Successful generation of micelles, vesicles, and/or worms with controllable sizes was achieved through the self-assembly process of the poly[N-(2-hydroxypropyl)]methacrylamide-g-polylactide (PHPMAA-g-PLA) graft copolymer within a microfluidic channel. A product diagram was created to illustrate various morphologies associated with different polymer concentrations, all while maintaining a constant flow velocity ratio between water and the polymer solution.

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Article information

DOI: https://doi.org/10.1039/D3NA01038D
Article type: Communication
Submitted: 23 Nov 2023
Accepted: 08 Mar 2024
First published: 11 Mar 2024
This article is Open Access

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Nanoscale Adv., 2024,6, 1992-1996

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Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation

S. L. Petrova, E. Pavlova, V. Pokorný and V. Sincari, Nanoscale Adv., 2024, 6, 1992 DOI: 10.1039/D3NA01038D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation†

Abstract

Supplementary files

Article information

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Effect of polymer concentration on the morphology of the PHPMAA-g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation

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