The department deals with x-ray structure analysis of biological macromolecules. We are mainly interested in detailed studies of proteins or protein complexes and ligands and their function but also in other crystallisable macromolecules. Protein samples are mostly prepared in collaboration with other laboratories.
Systematic analysis of interactions between proteins and synthetic polymers utilized in biomedical applications.
Fig. 1: A schematic representation of the structure determination process: single crystals of enzyme laccase, X-ray diffraction image, and a detail of structure of the studied enzyme: blue mesh - electron density contour, yellow sticks - interatomic bonds.
Fig. 2: Two perpendicular views of a hexamer of the enzyme catalysing hydrolysis of lactose. This macromolecular complex of beta-galactosidase from Arthrobacter sp. C2-2 represents information about spatial arrangement of 55000 non-hydrogen atoms of this cold-active enzyme.
More information about the department
Web page: http://protein.awardspace.com/
BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL
Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW
Centre of Biomedicinal Polymers - CBMP
Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
phone:+420 296 809 111
fax:+420 296 809 410