Laboratory of Polymer Nanotherapeutics

Research People Equipment Publications

(under BIOCEV program 4.1.1 Development of Polymer Therapeutics and Diagnostics for Treatment and Diagnostic of Cancer and Cardiovascular Diseases).

(Head Ing. Richard Laga, PhD.)

Research Areas

  • Polymer vaccines and immunostimulants
  • Polymer drug delivery systems
  • Polymer systems for nucleic acid delivery

Main Objectives

  • Development of new types of synthetic polymer vaccines consisting of a hydrophilic high-molecular weight or amphiphilic self-assembling polymer carrier, protein-based antigen and synthetic adjuvant for the infectious diseases prophylaxis and cancer diseases immunotherapy
  • Synthesis and characterization of new types of water-soluble and supramolecular stimuli-responsive polymer carriers of drugs for the site-specific treatment of neoplastic and inflammation diseases
  • Development of novel synthetic polycations used for complexation, targeted delivery and controlled release of nucleic acids (plasmid DNA, siRNA, miRNA); synthesis of reactive hydrophilic polymers for shielding of both viral and non-viral gene delivery vectors used for the treatment of cancer diseases

 

Content of the Research

The research activities of the Laboratory of Polymer Nanotherapeutics are primarily aimed at the study and development of polymer-drug conjugates with diverse biological functions for targeted therapy of infectious, neoplastic and inflammation diseases with a potential utilization in human medicine. The proposed polymer systems are composed of the hydrophilic or amphiphilic polymer carriers with different composition (e.g. polyacrylates, polymethacrylates, polymethacrylamides, polyethylene glycols, polyamino acids, etc.), valency of functional groups (telechelic, semi-telechelic, multivalent) and polymer chain architecture (e.g. linear, star-shaped, comb-like, micellar, etc.) that are covalently or non-covalently conjugated to the biologically active compounds (e.g. drugs, proteins, nucleic acids, etc.) through the stable or (hydrolytically, enzymatically or reductively) biodegradable  linkers. Furthermore, the polymer carriers offer a possibility to incorporate the targeting units and/or the fluorescent, radioisotope, or contrast labels to their structures thus facilitating active targeting of the conjugate to the therapeutic site of action or visualization of the conjugate by the imaging techniques, respectively. The Laboratory of Polymer Nanotherapeutics uses modern organic, polymer and bio-conjugation synthetic methods for the preparation of the tailor-made, highly defined materials as well as the sophisticated physiochemical techniques for the precise characterization of the synthesized material.

 

Potential for Cooperation

The Laboratory of Polymer Nanotherapeutics has established an outstanding cooperation with many internationally-recognized scientific groups led by e.g. Prof. Leonard Seymour (Department of Oncology, Oxford University, UK), Dr. Robert Seder (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA) or Prof. Karsten Mäder (Institute of Pharmacy, Martin-Luther-University, Germany), but it is open for new cooperation with academic and also non-academic subjects. We can offer to our potential partners the knowledges in the field of polymer and organic synthesis, bio-conjugation chemistry and physical chemistry of macromolecules. Our polymer systems can be used for the transport of broad range bioactive compounds. They are able to guarantee prolonged blood circulation time, reduced toxicity and controlled release of the bioactive compound directly in the therapeutic site of the action.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21