Jan Dohnálek, PhD
Consultant Dr.Tereza Skalova, PhD
Topic3D structure studies of natural killer cell receptors.
AnnotationMammalian immune system relies on a number of receptors recognizing virus infected or cancer cells. A special type of lymphocytes recognizes such cells via a row of surface receptors and upon positive identification of an enemy a cascade of events leading to lysis of the contacted cell is initiated. These natural killer cells can avoid cells of their own organism but attack effectively for instance virus-infected cells. The molecular mechanism of this recognition has not been fully understood yet. We elucidate structure and function of these surface receptors mostly by means of X-ray diffraction analysis. The work includes protein purification, characterisation, and crystallization, diffraction screening, data collection at synchrotron radiation sources, structure solution and interpretation.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21