Supervisor
(Consultant)
Jan Dohnálek, PhD
Consultant Dr.Tereza Skalova, PhD
Topic3D structure studies of natural killer cell receptors.
AnnotationMammalian immune system relies on a number of receptors recognizing virus infected or cancer cells. A special type of lymphocytes recognizes such cells via a row of surface receptors and upon positive identification of an enemy a cascade of events leading to lysis of the contacted cell is initiated. These natural killer cells can avoid cells of their own organism but attack effectively for instance virus-infected cells. The molecular mechanism of this recognition has not been fully understood yet. We elucidate structure and function of these surface receptors mostly by means of X-ray diffraction analysis. The work includes protein purification, characterisation, and crystallization, diffraction screening, data collection at synchrotron radiation sources, structure solution and interpretation.

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR
Heyrovského nám. 2
162 06 Prague 6
Czech Republic
tel:+420 296 809 111
fax:+420 296 809 410

Strategie 21