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From 4th June 2012 to 15th June 2012 in the Institute gallery of IMC AS CR, an exhibition P.O.L. E. art group:reconstruction of one exhibition from 1972 -1989 takes place
76 PMM Conference Polymers in Medicine is to be held in Prague on 1 - 5 July 2012. Career in Polymers 2012 workshop to take place before the conference.
MoDeSt 2012 conference is to be held in Prague from 2 to 6 September 2012
| Supervisor (Consultant) | Jan Dohnálek Consultant Tereza Skálová |
|---|---|
| Topic | Bacterial RNA polymerase - structural studies of the multiprotein complex. |
| Annotation | RNA polymerase transcribes the genetic code of DNA into RNA. It is a multi-protein complex, the funciton of which depends on some not entirely understood subunits or related proteins. Detailed knowledge of the structure and function of RNAp from a gram-positive bacterium will enable development of specifically targeted drugs based on inhibition of function. We study behaviour and structure of the whole RNAp complex and of its subunits with a focus on some recently discovered related proteins. The results should provide crucial new information about this key element of cell life funcitons. The project includes protein and complex stabilization, purification, characterisation, and crystallization, diffraction screening, data collection at synchrotron radiation sources, structure solution and interpretation. |
Center BIOPOL
Center BIOpolymer POstdoctoral Laboratory and educational center arises with finantial support from EU funds, operational programme Education for Competitiveness
Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410
