Supervisor
(Consultant)
Jan Dohnálek
Consultant Jarmila Dušková
Topic3D structure analysis of chitinolytic enzymes of bacterial microflora of the gastro-intestinal tract.
AnnotationBacteria inhabiting human gastro-intestinal tract express several enzymes capable of chitin cleavage. This complex of chitinolytic enzymes degrades chitin-containing cell walls of fungi and contributes to human health. A detailed study of enzymes of one of these bacteria provides important characteristics and properties of the molecules, including determination of their three-dimensional structure by the means of x-ray diffraction. The work is focused on enzyme isolation from bacterial extracts, their purification, activity assays,crystallization and determination of their three-dimensional structure by x-ray diffraction analysis followed by computational analysis of the obtained results.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21