Supervisor
(Consultant)
Eduard Brynda, PhD
Consultant Zdena Sedláková, PhD
TopicFunctional polymer brushes capable of preventing non-specific protein deposition
AnnotationDeposition of proteins from complex biological media, such as, blood plasma, serum, cell cultivation media, cell suspensions, or tissue extracts makes serious troubles for applications of artificial materials in biotechnologies and medicine. The aim of the work is the development of anti-fouling polymer layers which prevent protein adsorption and contain reactive chemical groups for covalent attachment of biologically active molecules. The layers will be synthesized as polymer brushes using controlled radical polymerization (ATRP, ARGET) of various hydrophilic acrylates, methacrylates, acrylamides, and methacrylamides initiated by reagents immobilized on surface of various substrates. IR reflection spectroscopy, ellipsometry, and AFM will be used for characterization of the layers. Surface plasmon resonance (SPR) will be used to observe their interaction with the biological fluids. Selected layers will be applied for preparation of biosensors and micro- and nano-particles in collaboration with biological and medical research teams. Continuation of the research is included in the program of Biotechnology and Biomedicine Centre of Academy of Sciences CR and Charles University, Prague

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21