Supervisor
(Consultant)
Eduard Brynda, PhD
Consultant ingCésar Rodriguéz-Emmeneger, PhD.
TopicProtein adsorption from complex biological fluids on synthetic surfaces
AnnotationProtein fouling from complex biological fluids impairs the functions of biotechnological and biomedical devices. Various artificial materials have been reported to be resistant to adsorption from simple protein solutions, however, a significant protein fouling from blood plasma or serum on their surfaces has been observed. The plasma adsorption cannot be explained by current theories of protein resistance so far based only on the adsorption from model single protein solutions. The research will be focused on searching relationship between the adsorption from various protein containing fluids, particularly blood plasma or serum, and chemical composition, structure, and physico-chemical properties of surfaces currently developed in the Institute of Macromolecular Chemistry AS CR. The experimental work will include preparation of ultrathin molecular layers of polymers on the material surfaces (polymer brushes) of various composition and their characterization by measuring thickness and swelling using ellipsometry, wettability by contact angles, morphology by SEM and AFM, chemical structure by reflection FTIR and protein adsorption by FTIR and SPR. The aim of the research is to gain experimental basis for elucidation protein adsorption from blood plasma.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21