Supervisor
(Consultant)
Martin Studenovský, Ph.D.
TopicPolymer carriers for drugs with new types of linkers
AnnotationThe standard low-molecular-weight drugs suffer from a number of principal drawbacks, including in particular their rapid elimination from the body, side toxicity, often poor solubility and non-specific action. However, if the given therapeutic agent is linked via an appropriate spacer to a suitable carrier the above-mentioned shortcomings can be completely eliminated. Long-time development has shown that the ideal carriers are water-soluble polymers such as poly(ethylene oxide), copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) and some others. Such polymers are completely nontoxic and biocompatible themselves, and, consequently, the active substances bound to them behave similarly. We talk about so-called polymer conjugates which can circulate in the blood several days, have significantly suppressed toxicity compared to the free drug and thanks to the possibility of passive or active targeting they can specifically act at the target site. However, the desired effect can be achieved only if the bond (linker) between polymer carrier and drug is long-term stable in blood circulation and also easily degraded in the site of action. This condition is further limited by the nature of the reactive groups useful for binding on the drug itself. As a result, only few well-functioning systems on that principle have been developed and described so far, and, in addition, for a very limited group of therapeutics. Aim of the project is the design and synthesis of polymer carriers based on HPMA copolymers with different types of reactive groups suitable for a wide range of drugs, in particular cancerostatics. The focal point will consist of organic and polymer synthesis, characterization of polymer systems using instrumental techniques and also of the work with scientific literature. Selected conjugates will be then tested by the cooperating biologists in terms of their therapeutic activity.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21