Supervisor
(Consultant)
Libor Kostka, PhD
TopicWell-defined high molecular weight polymeric drug carriers
AnnotationSynthesis and study of properties of well-defined high molecular weight polymer drug carriers based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers is the aim of this project. These drug carriers will be synthetized by controlled radical polymerization technique, mainly RAFT. This technique is beneficial for the synthesis of the polymer carriers with diverse architecture, like diblock copolymers, star-shaped carriers or micellar structures. Such drug carriers enable specific delivery of cytotoxic drugs to solid tumors. Due to the innovative synthesis the covalent attachment of drugs to the carrier system via intracellularly degradable spacers will be achieved. Polymer drug carriers will be characterized by various physico-chemical methods. Their biological activity will be evaluated in vitro on cell cultures by the student themselves. Further biological evaluation of prepared samples will be solved in cooperation with our local and foreign partner biologicists. The student will broaden their knowledge in the field of novel drug delivery and they will learn new skills of modern polymerization techniques and synthetic and instumental methods.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21