Supervisor
(Consultant)
MS.Tomáš Etrych, PhD.
TopicStimuli-responsive nanogels as multistage drug delivery systems for efficient tumor treatment
AnnotationSynthesis and study of properties of well-defined high molecular weight polymer nanogels or star-like polymers serving as drug carriers for anti-cancer drugs and inhibitors of anti-apoptotic proteins is the aim of this project. These drug carriers will be synthetized by controlled solution or emulsion radical polymerization technique. The polymer carriers will be designed as biodegradable structures, which undergo stimuli-sensitive degradation within peripheral tumor part to fragments enabling rapide extravasation into the tumor and drug release. Disertation will be based on the polymer synthesis par and physico-chemical characterisation of polymer material. Their biological activity will be evaluated in vitro on cell cultures by the student themselves. Further biological evaluation of prepared samples will be solved in cooperation with our local and foreign partner biologicists. The student will broaden their knowledge in the field of novel drug delivery and they will learn new skills of modern polymerization techniques and synthetic and instumental methods.

BIOpolymer POstdoctoral Laboratory and educational center - BIOPOL

Otto Wichterle Centre of Polymer Materials and Technologies - CPMTOW

Centre of Biomedicinal Polymers - CBMP

Centre of Polymer Sensors - CPS

Polymers for Power Engineering - Energolab


 

Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410

Strategie 21