TOXICITY OF MONOMERS HEMA, DEGMA AND AEMA, USED TO SYNTHESIS OF HYDROGELS FOR MEDICAL APPLICATIONS
Chemical abstracts: 126:195198
Schneiderka P., Roosova M., Jojkova K., Prokes J., Labsky J., Vacik J. (First Faculty of Med., Charles Univ., Prague, Czech Rep.). Sb. Lek., 97(3), 351-367 (English) 1996 Univerzita Karlova CODEN: SBLEA2. ISSN: 0036-5327. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology)
Acute toxicity parameters (LDs) were evaluated and calcd. after i.m. and i.p. administration of 2-hydroxyethyl methacrylate (HEMA), 2-(hydroxyethoxy)ethyl methacrylate (DEGMA) and 2-(acetoxy)ethyl methacrylate (AEMA) to rats. Our previous findings were revisited and cor. Hematol. parameters revealed low sensitivity to the toxic substances.
A NOVEL HYDROPHILIC CROSSLINKER IN PREPARATION OF HYDROPHILIC SORBENTS
Chemical abstracts: 127:34926
Horak D., Labsky J. (Inst. Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 162 06, Czech Rep.). React. Funct. Polym., 32(3), 277-280 (English) 1997 Elsevier CODEN: RFPOF6. ISSN: 1381-5148. DOCUMENT TYPE: Journal CA Section: 37 (Plastics Manufacture and Processing) Section cross-reference(s): 38
A new highly hydrophilic crosslinking agent, 2,3-dihydroxybutane-1,4-diyl dimethacrylate (DHDM), was synthesized from 1,2:3,4-diepoxybutane by reaction with methacrylic acid. Highly hydrophilic spherical particles were prepd. by suspension copolymn. of 2-hydroxyethyl methacrylate (HEMA) with DHDM in an aq. medium in the presence of cyclohexanol and 1-dodecanol as inert diluents. Porous properties of HEMA-DHDM copolymer were compared with those of com. available poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) and poly(glycidyl methacrylate-co-ethylene dimethacrylate) sorbents.